PrimeReplace Atlas

PrimeReplace Atlas maps ClinVar pathogenic/likely pathogenic variants onto MANE/GENCODE transcript structures to show how disease-associated variant burden is distributed across exons, exon blocks, and coding-payload units.

It provides a pre-implementation architecture layer for evaluating how public pathogenic variant records are distributed across transcript units relevant to large-fragment genome-writing hypotheses.

The atlas does not predict editing efficiency, safety, therapeutic efficacy, or patient coverage; it provides a pre-implementation target-architecture map.

Browser: https://best916116-crypto.github.io/PrimeReplace-Atlas/
Repository: https://github.com/best916116-crypto/PrimeReplace-Atlas
Zenodo archive: https://doi.org/10.5281/zenodo.20338345
Current release: v1.0.1, 2026-05-22
Release notes: reports/release_notes_v1.0.1.md
Data dictionary: reports/data_dictionary_v1.0.0.md
Validation summary: validation/public_release_checks_v1.0.1.json

Workflow schematic

The schematic summarizes the release logic: public ClinVar/MANE/GENCODE resources are mapped onto transcript units, converted into architecture labels and payload/context caveats, and exposed through browser pages and downloadable release tables. The claim boundary is explicit: PrimeReplace Atlas is a pre-implementation architecture resource, not an editing-efficiency, safety, patient-coverage, therapeutic-efficacy, or modality-recommendation system.

What it does

PrimeReplace Atlas converts public disease-associated variant records into transcript-level architecture summaries.

In practical terms, the atlas helps answer whether ClinVar P/LP records for a gene are: